一、基本信息

 张涛，男，1987年8月生，山西灵石人，工学博士，纳微复合材料与器件重点实验室博士后,重庆科技学院2021年引进人才，硕士生导师。主要从事环境与人类健康、遗传发育与疾病等相关研究。主持重庆市博士后自然科学基金、博士后特别资助项目及重庆市面上项目等多项省部级课题。参与国家自然科学基金重点项目1项。参与指导学生参加“挑战杯”等各类竞赛获得省部级、校级特等奖、一等奖3项。以第一/通讯作者发表学术论文十余篇，其中TOP期刊和自然指数期刊共3篇。

二、教育背景

2005.09-2009.07，西南大学，大学本科

2009.09-2013.07，西南大学，理学硕士

2013.09-2019.07，重庆大学，工学博士

三、工作履历

2019.07-2021.09，重庆大学，博士后

2021.09至今，重庆科技学院，冶金与材料工程学院，讲师

四、研究领域

心脑血管的遗传发育与人类疾病、环境污染物与人类健康

1. 代表性成果(包括科研成果和教学成果)

2. Yi chen, Yingjie Fan, Zichen xu, Xiaoling Liao, Wenfeng Xu*, Tao Zhang*. Comprehensive Review of Toxicity of Coal Fly Ash and its Leachate in the Ecosystem. Ecotoxicology and Environmental Safety. Dec 29 2023.

3. Zhang L, Chen Y, Zhou Z, Wang Z, Fu L, Zhang L, Xu C, Loor JJ, Wang G, Zhang T*, Dong X. Vitamin C injection improves antioxidant stress capacity through regulating blood metabolism in post-transit yak. Sci Rep. 2023 Jun 23;13(1):10233. doi: 10.1038/s41598-023-36779-w. PMID: 37353533; PMCID: PMC10290073.

4. Xu Z, Chen Y, Wang Y, Han W, Xu W, Liao X, Zhang T*, Wang G*. Matrix stiffness, endothelial dysfunction and atherosclerosis. Mol Biol Rep. 2023 Aug;50(8):7027-7041. doi: 10.1007/s11033-023-08502-5. Epub 2023 Jun 29. PMID: 37382775.

5. Zhang T, Xu Z, Wen L, Lei D, Li S, Wang J, Huang J, Wang N, Durkan C, Liao X, Wang G. Cadmium-induced dysfunction of the blood-brain barrier depends on ROS-mediated inhibition of PTPase activity in zebrafish. J Hazard Mater. 2021 Jun 15;412:125198. doi: 10.1016/j.jhazmat.2021.125198. Epub 2021 Jan 21. PMID: 33550130.

6. Zhang T, Wang Q, Wang Y, Wang J, Su Y, Wang F, Wang G. AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux. J Transl Med. 2019 May 17;17(1):161. doi: 10.1186/s12967-019-1910-7. PMID: 31101050; PMCID: PMC6524272.

7. Wen L^#, Zhang T^#, Wang J, Jin X, Rouf MA, Luo D, Zhu Y, Lei D, Gregersen H, Wang Y, Wang G. The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics. PLoS Genet. 2021 Jul 28;17(7):e1009690. doi: 10.1371/journal.pgen.1009690. PMID: 34319989; PMCID: PMC8318303.

   Wang J, Xu J, Zang G, Zhang T, Wu Q, Zhang H, Chen Y, Wang Y, Qin W, Zhao S, Qin E, Qiu J, Zhang X, Wen L, Wang Y, Wang G. trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis. Research (Wash D C). 2022 Apr 4;2022:9839368. doi: 10.34133/2022/9839368. PMID: 35465346; PMCID: PMC9006154.

8. Lei D, Zhang X, Rouf MA, Mahendra Y, Wen L, Li Y, Zhang X, Li L, Wang L, Zhang T, Wang G, Wang Y. Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 2021 Oct 30;24(11):103386. doi: 10.1016/j.isci.2021.103386. PMID: 34816109; PMCID: PMC8593614.

9. Xia S, Zhu X, Yan Y, Zhang T, Chen G, Lei D, Wang G. Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish. Ecotoxicol Environ Saf. 2021 May 8;218:112308. doi: 10.1016/j.ecoenv.2021.112308. Epub ahead of print. PMID: 33975224.

10. Vania V, Wang L, Tjakra M, Zhang T, Qiu J, Tan Y, Wang G. The interplay of signaling pathway in endothelial cells-matrix stiffness dependency with targeted-therapeutic drugs. Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165645. doi: 10.1016/j.bbadis.2019.165645. Epub 2019 Dec 19. Erratum in: Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1;1867(7):166140. PMID: 31866415.

11. Ren J, Tang CZ, Li XD, Niu ZB, Zhang BY, Zhang T, Gao MJ, Ran XZ, Su YP, Wang FC. Identification of G2/M phase transition by sequential nuclear and cytoplasmic changes and molecular markers in mice intestinal epithelial cells. Cell Cycle. 2018;17(6):780-791. doi: 10.1080/15384101.2018.1426416. Epub 2018 Apr 10. PMID: 29338545; PMCID: PMC5969559.

    Hu J, Qiu J, Zheng Y, Zhang T, Yin T, Xie X, Wang G. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling. Ann Biomed Eng. 2016 May;44(5):1462-74. doi: 10.1007/s10439-015-1442-0. Epub 2015 Sep 8. Erratum in: Ann Biomed Eng. 2016 Mar;44(3):830-2. PMID: 26350504.

    陈 裔, 张 涛，徐文峰*, 廖晓玲*. 检测中性粒细胞趋化性的微流控器件研究进展[J]. 山东化工.

    陈 裔, 徐文峰, 廖晓玲, 张 涛* . CD63介导β1-integrin调控斑马鱼尾静脉血管修剪的血流动力学机制. 第八届中美生物医学暨海内外力术研讨会.

    陈 裔, 黄 宇, 汪 鹏, 肖湘锐, 张涛* . Low-Iron-Diet Promotes Radiation-Induced Intestinal Damage Repair via Stem Cell -Mediated Epithelial Regeneration. 2023中国生物医学工程大会暨创新医疗峰会.

    教学成果：

    指导学生获得第十七届“挑战杯”，校级，特等奖，指导教师（徐文峰、廖晓玲、张涛）

    指导学生获得第十七届“挑战杯”，重庆市，一等奖，指导教师（徐文峰、廖晓玲、张涛）

    指导学生获得第十三届“挑战杯”，创业计划竞赛，银奖，指导教师（徐文峰、张涛、廖晓玲）

    第十三届“挑战杯”中国大学生创业竞赛，重庆赛区，优秀指导教师，张涛